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This is an old revision of Cell Sheets made by hildur on 2014-06-24 08:29:49.

 

Epithelial sheet


This project focuses on understanding and explaining how cells in a 1D sheet interact with neighbouring cells and how they grow, divide and migrate.

Zebrafish primordium formation


The zebrafish posterior lateral line primordium formation is often used as a model for collective cell migration and cell polarity.
A cohesive cluster of over 100 cells, which originates posterior to the ear, migrates along the embryonic trunk. The cluster polarizes along a gradient of SDF-1 which is expressed in a narrow line along the horizontal myoseptum. During migration cells in the trailing two thirds of the primordium organize into two or three garlic bulb-shaped rosettes. At regular intervals a cluster of 20-30 cells gets deposited from the migrating cluster.


References:


A. Aman and T. Piotrowski, Multiple signaling interactions coordinate collective cell migration of the posterior lateral line primordial: Page Titlehttp://www.landesbioscience.com/journals/celladhesion/AmanCAM3-4.pdf

E.Y. Ma and D.W. Raible, Signaling Pathways Regulating Zebrafish Minireview Lateral Line Development: Page Titlehttp://www.sciencedirect.com/science/article/pii/S0960982209009117
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