Revision [118]

This is an old revision of Cell Sheets made by hildur on 2014-06-27 08:53:42.


Epithelial sheet

This project focuses on understanding and explaining how cells in a 1D sheet interact with neighbouring cells and how they grow, divide and migrate.

Zebrafish primordium formation

The zebrafish posterior lateral line primordium formation is often used as a model for collective cell migration and cell polarity.
A cohesive cluster of over 100 cells, which originates posterior to the ear, migrates along the embryonic trunk. The cluster polarizes along a gradient of SDF-1 which is expressed in a narrow line along the horizontal myoseptum. During migration cells in the trailing two thirds of the primordium organize into two or three garlic bulb-shaped rosettes. At regular intervals a cluster of 20-30 cells gets deposited from the migrating cluster.


A. Aman and T. Piotrowski, Multiple signaling interactions coordinate collective cell migration of the posterior lateral line primordial: Page Title

E.Y. Ma and D.W. Raible, Signaling Pathways Regulating Zebrafish Minireview Lateral Line Development: Page Title

E. D. Costanzoa et al., A hybrid mathematical model for self-organizing cell migration in the zebrafish lateral line: Page Title

J.R. Collier et al., A cell Cycle Model for Somitogenesis: Mathematical Formulation and Numerical Simulation: Page Title

Collective cell migration

Collective motion of cells plays an important role in development as well as processes like cancer and wound healing.
When sheets or clusters of cells move together the cells remain connected, the sheet or cluster maintains multicellular polarity and the sheet or cluster structurally modifies the surrounding tissue and migration path.


A. Abeta et al., A Mathematical Model to Study the Dynamics of Epithelial Cellular Networks: Page Title

N. SepĂșlveda et al., Collective Cell Motion in an Epithelial Sheet Can Be Quantitatively Described by a Stochastic Interacting Particle Model: Page Title

L. Petitjean et al., Velocity Fields in a Collectively Migrating Epithelium: Page Title
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